Why am I passionate about this?

Frank S. David, MD, PhD leads the biopharma consulting firm Pharmagellan, where he advises drug companies and investors on R&D and business strategy. He is also an academic researcher on strategy, regulation, and policy in the drug industry; a member of the Harvard-MIT Center for Regulatory Science; and a former blogger at Forbes.com.


I wrote

The Pharmagellan Guide to Analyzing Biotech Clinical Trials

By Frank S. David,

Book cover of The Pharmagellan Guide to Analyzing Biotech Clinical Trials

What is my book about?

If you're a biotech executive, investor, adviser, or entrepreneur -- or aspire to be one --  you’re supposed to understand clinical…

When you buy books, we may earn a commission that helps keep our lights on (or join the rebellion as a member).

The books I picked & why

Book cover of The Billion-Dollar Molecule: The Quest for the Perfect Drug

Frank S. David Why did I love this book?

This account of the early years of Vertex Pharmaceuticals, from its inception as a scrappy start-up to its early work in HIV, is a must-read classic for anyone interested in how science turns into new drugs. Barry Werth’s journalistic play-by-play is a cinematic, true-to-life picture of the strategic decisions, real-world challenges, and larger-than-life personalities that underlie modern drug development. His riveting follow-up, The Antidote, continues the saga by taking readers through Vertex’s pathbreaking work to transform the care of patients with hepatitis C and cystic fibrosis.

By Barry Werth,

Why should I read it?

1 author picked The Billion-Dollar Molecule as one of their favorite books, and they share why you should read it.

What is this book about?

Synopsis coming soon.......


Book cover of Malignant: How Bad Policy and Bad Evidence Harm People with Cancer

Frank S. David Why did I love this book?

Since Nixon’s "War on Cancer," oncology treatment has seen some great advances, but also the approval of scores of over-priced drugs that do little to improve patients’ quality or quantity of life. Oncologist Vinay Prasad has written a broad, accessible overview of the flaws of modern cancer drug development that spans clinical trial design, conflicts of interest, regulatory policy, and more. His unabashedly anti-pharma stance gets preachy in places, but most of the challenges he identifies are spot-on and provide a thought-provoking roadmap for the future.

By Vinayak K. Prasad,

Why should I read it?

1 author picked Malignant as one of their favorite books, and they share why you should read it.

What is this book about?

How hype, money, and bias can mislead the public into thinking that many worthless or unproven treatments are effective.

Each week, people read about new and exciting cancer drugs. Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel-but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology…


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Book cover of I Am Taurus

I Am Taurus by Stephen Palmer,

The constellation we know as Taurus goes all the way back to cave paintings of aurochs at Lascaux. This book traces the story of the bull in the sky, a journey through the history of what has become known as the sacred bull.

Each of the sections is written from…

Book cover of The Great American Drug Deal: A New Prescription for Innovative and Affordable Medicines

Frank S. David Why did I love this book?

What do we mean when we say “drug prices are too high” – and how can we fix them? In clear prose, Peter Kolchinsky, a successful biotech investor at RA Capital, clarifies the difference between list, net, and out-of-pocket drug costs, and explains how various parts of the system – drug companies, insurers, and pharmacy benefit managers (PBMs) – fit together to determine them. He also includes several detailed and timely suggestions for reform that would reduce the burden on patients and sustain biopharma innovation.

By Peter Kolchinsky,

Why should I read it?

2 authors picked The Great American Drug Deal as one of their favorite books, and they share why you should read it.

What is this book about?

Developing life-changing drugs is risky and expensive—but that’s not what makes them unaffordable.Drug pricing is a staple of every news cycle and political debate. And while we’ve struggled for decades to agree on solutions that serve all patients without jeopardizing the invention of new medicines, many Americans suffer because they can’t afford the drugs they need.Do we really have to choose between affordability and innovation?In The Great American Drug Deal, scientist and industry expert Peter Kolchinsky answers this question with a decisive No. The pharmaceutical industry’s commitment to creating new lifesaving drugs destined to become inexpensive generics can be balanced…


Book cover of The Right Price: A Value-Based Prescription for Drug Costs

Frank S. David Why did I love this book?

A key issue about drug pricing not covered in Kolchinsky's book relates to value: even if a new therapy is affordable, is it "worth it"? Health economist Peter Neumann and his colleagues have written an authoritative, insightful, and extremely accessible history of efforts to align drugs' prices with their benefits to patients and society. This is a must-read guide for both insiders and non-experts to a topic that will be at the forefront of the drug pricing debate in the coming decade. 

By Peter J. Neumann, Joshua T. Cohen, Daniel A. Ollendorf

Why should I read it?

1 author picked The Right Price as one of their favorite books, and they share why you should read it.

What is this book about?

The US prescription drug business is a $500 billion industry whose rising prices carry profound consequences for patients, caregivers, employers and taxpayers across the nation. In the United States, average prices of leading brand-name drugs are two to four times higher than prices charged in other wealthy countries, raising questions as to what Americans are getting for the extra expense. On the other hand, healthy industry returns have arguably fueled life-saving
innovation. With the advent of ever more targeted and powerful treatments, including cell- and gene-based therapies with multi-million-dollar price tags, the need for sensible drug pricing policies will only…


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Book cover of Locked In Locked Out: Surviving a Brainstem Stroke

Locked In Locked Out by Shawn Jennings,

Can there be life after a brainstem stroke?

After Dr. Shawn Jennings, a busy family physician, suffered a brainstem stroke on May 13, 1999, he woke from a coma locked inside his body, aware and alert but unable to communicate or move. Once he regained limited movement in his left…

Explore my book 😀

The Pharmagellan Guide to Analyzing Biotech Clinical Trials

By Frank S. David,

Book cover of The Pharmagellan Guide to Analyzing Biotech Clinical Trials

What is my book about?

If you're a biotech executive, investor, adviser, or entrepreneur -- or aspire to be one --  you’re supposed to understand clinical trial results. But what if you’re not an expert in study design or biostatistics? The Pharmagellan Guide to Analyzing Biotech Clinical Trials will give you the foundation you need to analyze journal articles, press releases, and investor presentations about studies of new drugs with more confidence.

Book cover of The Billion-Dollar Molecule: The Quest for the Perfect Drug
Book cover of Malignant: How Bad Policy and Bad Evidence Harm People with Cancer
Book cover of The Great American Drug Deal: A New Prescription for Innovative and Affordable Medicines

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